Anterolateral entorhinal cortex thickness as a new biomarker for early detection of Alzheimer's disease.

ABSTRACT:

Introduction

Loss of entorhinal cortex (EC) layer II neurons represents the earliest Alzheimer's disease (AD) lesion in the brain. Research suggests differing functional roles between two EC subregions, the anterolateral EC (aLEC) and the posteromedial EC (pMEC).

Methods

We use joint label fusion to obtain aLEC and pMEC cortical thickness measurements from serial magnetic resonance imaging scans of 775 ADNI-1 participants (219 healthy; 380 mild cognitive impairment; 176 AD) and use linear mixed-effects models to analyze longitudinal associations among cortical thickness, disease status, and cognitive measures.

Results

Group status is reliably predicted by aLEC thickness, which also exhibits greater associations with cognitive outcomes than does pMEC thickness. Change

SUBMITTER: Holbrook AJ 

PROVIDER: S-EPMC7447874 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature