Risk assessment of chlorinated paraffins in feed and food.

ABSTRACT: The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of chlorinated paraffins in feed and food. The data for experimental animals were reviewed and the CONTAM Panel identified the liver, kidney and thyroid as the target organs for the SCCP and MCCP mixtures tested in repeated dose toxicity studies. Decreased pup survival and subcutaneous haematoma/haemorrhage were also identified as critical effects for an MCCP mixture. For the LCCP mixtures tested, the liver was identified as the target organ. The Panel selected as reference points a BMDL ₁₀ of 2.3 mg/kg bw per day for increased incidence of nephritis in male rats, and of 36 mg/kg bw per day for increased relative kidney weights in male and female rats for

SUBMITTER: EFSA Panel on Contaminants in the Food Chain (CONTAM) 

PROVIDER: S-EPMC7447893 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature