Leprosy transmission in endemic and non-endemic areas based on the profile of antibody response of PGL-1 and PCR detection of Mycobacterium leprae DNA from nasal swab among healthy children of East Java, Indonesia.

ABSTRACT:

Background

East Java has become one of the provinces that have higher prevalence of leprosy, especially in the coastal region. Environment has also influenced for leprosy transmission and early detection could reduce the incidence rate of new leprosy cases. Epidemiological studies of leprosy in children can give an illustration of the important aspects of the environment. Presence of Mycobacterium leprae (M. leprae) DNA in nasal swabs and seropositivity level among them can describe M. leprae exposure in that area.

Objective

Analyzing PCR from nasal swab and seropositivity level among elementary school children between northern coast and southern coast of East Java province.

Methods

Five hundred and thirty children in Pacitan and Lamongan were inv

SUBMITTER: Adriaty D 

PROVIDER: S-EPMC7447951 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature