Altered phobic reactions in frontotemporal dementia: A behavioural and neuroanatomical analysis.

ABSTRACT:

Introduction

Abnormal behavioural and physiological reactivity to emotional stimuli is a hallmark of frontotemporal dementia (FTD), particularly the behavioural variant (bvFTD). As part of this repertoire, altered phobic responses have been reported in some patients with FTD but are poorly characterised.

Methods

We collected data (based on caregiver reports) concerning the prevalence and nature of any behavioural changes related to specific phobias in a cohort of patients representing canonical syndromes of FTD and Alzheimer's disease (AD), relative to healthy older controls. Neuroanatomical correlates of altered phobic reactivity were assessed using voxel-based morphometry.

Results

46 patients with bvFTD, 20 with semantic variant primary progressive aphasia, 25 with

SUBMITTER: Jimenez DA 

PROVIDER: S-EPMC7447974 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature