Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy.

ABSTRACT: The "canonical" function of Pax7+ muscle stem cells (satellite cells) during hypertrophic growth of adult muscle fibers is myonuclear donation via fusion to support increased transcriptional output. In recent years, however, emerging evidence suggests that satellite cells play an important secretory role in promoting load-mediated growth. Utilizing genetically modified mouse models of delayed satellite cell fusion and in vivo extracellular vesicle (EV) tracking, we provide evidence for satellite cell communication to muscle fibers during hypertrophy. Myogenic progenitor cell-EV-mediated communication to myotubes in vitro influences extracellular matrix (ECM)-related gene expression, which is congruent with in vivo overload experiments involving satellite cell depletion

SUBMITTER: Murach KA 

PROVIDER: S-EPMC7448100 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature