Pulmonary vessel casting in a rat model of monocrotaline-mediated pulmonary hypertension.

ABSTRACT: Pulmonary hypertension is a chronic vascular disease characterized by pulmonary vasoconstriction and pulmonary arterial remodeling. Pulmonary arterial remodeling is mainly due to small pulmonary arterial wall thickening and lumen occlusion. Previous studies have described intravascular changes in lung sections using histopathology, but few were able to obtain a fine detailed image of the pulmonary vascular system. In this study, we used Microfil compounds to cast the pulmonary arteries in a rat model of monocrotaline-induced pulmonary hypertension. High-quality images that enabled quantification of distal pulmonary arterial branching based on the number of vessel bifurcations/junctions were demonstrated in this model. The branch and junction counts of distal pulmonary arteries significantl

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7448137 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature