Parkinson disease clinical subtypes: key features & clinical milestones.

ABSTRACT:

Objectives

Based on multi-domain classification of Parkinson disease (PD) subtypes, we sought to determine the key features that best differentiate subtypes and the utility of PD subtypes to predict clinical milestones.

Methods

Prospective cohort of 162 PD participants with ongoing, longitudinal follow-up. Latent class analysis (LCA) delineated subtypes based on score patterns across baseline motor, cognitive, and psychiatric measures. Discriminant analyses identified key features that distinguish subtypes at baseline. Cox regression models tested PD subtype differences in longitudinal conversion to clinical milestones, including deep brain stimulation (DBS), dementia, and mortality.

Results

LCA identified distinct subtypes: "motor only" (N = 63) characterized by prim

SUBMITTER: Campbell MC 

PROVIDER: S-EPMC7448190 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature