Identification of New Targets and the Virtual Screening of Lignans against Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is characterized by the progressive disturbance in cognition and affects approximately 36 million people, worldwide. However, the drugs used to treat this disease are only moderately effective and do not alter the course of the neurodegenerative process. This is because the pathogenesis of AD is mainly associated with oxidative stress, and current drugs only target two enzymes involved in neurotransmission. Therefore, the present study sought to identify potential multitarget compounds for enzymes that are directly or indirectly involved in the oxidative pathway, with minimal side effects, for AD treatment. A set of 159 lignans were submitted to studies of QSAR and molecular docking. A combined analysis was performed, based on ligand and structure, followed by the

SUBMITTER: Dos Santos Maia M 

PROVIDER: S-EPMC7448245 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature