Ultrasound assessment of skin thickness and stiffness: the correlation with histology and clinical score in systemic sclerosis.

ABSTRACT:

Background

Ultrasound is a useful tool to evaluate and quantify skin lesions. Few studies have assessed the criterion validity of skin ultrasound in systemic sclerosis (SSc). The aims of the study were to investigate skin thickness and stiffness using ultrasound and shear wave elastography (SWE) in SSc and to validate skin ultrasound measurements against histological skin thickness.

Methods

A total of 22 patients with diffuse cutaneous SSc (dcSSc), 22 with limited cutaneous SSc (lcSSc), and 22 age- and gender-matched healthy controls were enrolled. Skin thickness and stiffness were measured by B-mode ultrasound with SWE imaging on the bilateral fingers and hands. Additional ultrasound evaluation was carried out in 13 patients (9 dcSSc and 4 lcSSc) on their dorsal forearms, f

SUBMITTER: Chen C 

PROVIDER: S-EPMC7448329 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature