Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer.

ABSTRACT:

Background

Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to investigate its potential utility as a target for the development of therapeutic antibodies (Abs).

Methods

Transcriptome and bioinformatics analyses of human GC cell lines identified the neuronal pentraxin receptor (NPTXR) as a candidate molecule. NPTXR function was probed by modulating its expression in GC cells and assessing the effects on intracellular signaling and malignant behaviors in vitro and in mouse xenograft models. We also generated anti-NPTXR Abs and Nptxr^-/- mice, and assessed the clinical significance of NPTXR expression in GC specimens.

Results

NPTXR mRNA exp

SUBMITTER: Kanda M 

PROVIDER: S-EPMC7448342 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature