Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure.

ABSTRACT: Substance use disorders (SUDs) reflect genetic and environmental factors. While identifying reliable genetic variants that predispose individuals to developing SUDs has been challenging, epigenetic factors may also contribute to the heritability of SUDs. Familial drug use associates with a wide range of problems in children, including an increased risk for developing a SUD. The implications of maternal drug use on offspring development are a well-studied area; however, paternal drug use prior to conception has received relatively little attention. Paternal exposure to several environmental stimuli (i.e. stress or diet manipulations) results in behavioral and epigenetic changes in offspring. The purpose of this review is to determine the state of the preclinical literature on the behavioral

SUBMITTER: Nieto SJ 

PROVIDER: S-EPMC7448378 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature