MicroRNA‑188‑5p inhibits the progression of breast cancer by targeting zinc finger protein 91.

ABSTRACT: Breast cancer (BC) is the most commonly diagnosed malignant cancer in women. BC is the main cause of cancer‑related death in women and seriously threatens the life and health of women worldwide. MicroRNAs (miRNAs/miRs) have been reported to regulate the development and progression of different types of cancer. However, the regulatory functions of miR‑188‑5p in BC have not been thoroughly demonstrated. In this present research, we identified that miR‑188‑5p was downregulated in BC tissues and several BC cell lines. Downregulation of miR‑188‑5p was significantly associated with advanced TNM stage. Moreover, we identified that miR‑188‑5p mimics significantly inhibited proliferation using CCK‑8 assay, colony formation and xenograft animal model, suppressed invasion and migration detected by Tr

SUBMITTER: Yang Z 

PROVIDER: S-EPMC7448417 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature