A genetic predictive model for precision treatment of diffuse large B-cell lymphoma with early progression.

ABSTRACT:

Background

Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative treatment for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to develop a genetic predictive model for early progression and evaluate its potential in advancing alternative treatment.

Methods

Thirty-two hotspot driver genes were examined in 145 DLBCL patients and 5 DLBCL cell lines using next-generation sequencing. The association of clinical features, cell-of-origin, double expression, positive p53 protein, and gene alterations with early progression was analyzed, and the genetic predictive model was developed based on the related independent variables and assessed by the area under receiver operating characteristic. The poten

SUBMITTER: Ma J 

PROVIDER: S-EPMC7448459 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature