Surface Immobilization Chemistry of a Laminin-Derived Peptide Affects Keratinocyte Activity.

ABSTRACT: Many chemical routes have been proposed to immobilize peptides on biomedical device surfaces, and in particular, on dental implants to prevent peri-implantitis. While a number of factors affect peptide immobilization quality, an easily controllable factor is the chemistry used to immobilize peptides. These factors affect peptide chemoselectivity, orientation, etc., and ultimately control biological activity. Using many different physical and chemical routes for peptide coatings, previous research has intensely focused on immobilizing antimicrobial elements on dental implants to reduce infection rates. Alternatively, our strategy here is different and focused on promoting formation of a long-lasting biological seal between the soft tissue and the implant surface through transmembrane, cell

SUBMITTER: Fischer NG 

PROVIDER: S-EPMC7448695 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature