A Unified Mathematical Model for Nano-Liposomal Drug Delivery to Solid Tumors.

ABSTRACT: Nanoparticles, such as liposomes, allow more targeted drug delivery for improved efficacy and/or reduced toxicity in both passive (e.g., Doxil) or active [e.g., thermo-sensitive liposomes (TSL)] release forms compared with unencapsulated drugs (i.e., conventional chemotherapy). Optimization and evaluation of these different drug delivery systems are experimentally challenging because of varying tissue parameters as well as limited avaiability of experimental data. Here, we present a novel unified mathematical model that can simulate various liposomal drug delivery systems and unencapsulated drugs with a single set of equations. We use this model to evaluate the chemotherapy performance of free Doxorubicin (as drug), as well as various liposomal drug delivery systems: 1) passive liposomes (

SUBMITTER: Asemani D 

PROVIDER: S-EPMC7448813 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature