Ontology highlight
ABSTRACT:
SUBMITTER: Colletti M
PROVIDER: S-EPMC7448845 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Journal of extracellular vesicles 20200603 1
Bone marrow (BM) is the major target organ for neuroblastoma (NB) metastasis and its involvement is associated with poor outcome. Yet, the mechanism by which NB cells invade BM is largely unknown. Tumour microenvironment represents a key element in tumour progression and mesenchymal stromal cells (MSCs) have been recognized as a fundamental part of the associated tumour stroma. Here, we show that BM-MSCs isolated from NB patients with BM involvement exhibit a greater osteogenic potential than MS ...[more]