A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms.

ABSTRACT:

Background

Novel and new therapeutic strategies capable of enhancing the efficacy of existing antimicrobials is an attractive proposition to meet the needs of society.

Objective

This study aimed to evaluate the potentiating effect of a miconazole (MCZ) nanocarrier system, incorporated with iron oxide nanoparticles (IONPs) and chitosan (CS) (IONPs-CS-MCZ). This was tested on three representative complex interkingdom oral biofilm models (caries, denture and gingivitis).

Materials and methods

The planktonic and sessile minimum inhibitory concentrations (MICs) of IONPs-CS-MCZ against different Candida albicans strains were determined, as well as against all represented bacterial species that formed within the three biofilm models. Biofilms were treated for 24 hours

SUBMITTER: Arias LS 

PROVIDER: S-EPMC7448886 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature