Comparison of in vivo pathogenicity of four Candida auris clades in a neutropenic bloodstream infection murine model.

ABSTRACT: Candida auris is an emerging worldwide concern, but comparative data about the virulence of different C. auris lineages in mammalian hosts is lacking. Different isolates of the four prevalent C. auris clades (South Asian n = 5, East Asian n = 4, South African n = 5, and South American n = 5) were compared to assess their virulence in a neutropenic murine bloodstream infection model with C. albicans as reference. C. auris, regardless of clade, proved to be less virulent than C. albicans. Highest overall mortality at day 21 was observed for the South American clade (96%), followed by the South Asian (80%), South African (45%) and East Asian (44%) clades. Fungal burden results showed close correlation with lethality. Histop

SUBMITTER: Forgacs L 

PROVIDER: S-EPMC7448943 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature