Development and Preliminary Validation of a New Patient-Reported Outcome Measure for Chronic Rhinosinusitis (CRS-PRO).

ABSTRACT:

Background

Patient-reported outcome (PRO) measures developed and validated on patients with the currently defined phenotypes of chronic rhinosinusitis (CRS) are needed to support clinical trials in CRS.

Objective

This study developed and examined the initial reliability and validity of the CRS-PRO, a new PRO measure of CRS.

Methods

Instrument development was performed through structured interviews and focus groups with clinical experts and 45 patients with CRS meeting current definitions of disease, 21 patients with CRS without nasal polyps (CRSsNP), and 24 patients with CRS with nasal polyps (CRSwNP) to identify items important to patients. Then another 50 patients (32 with CRSsNP and 18 with CRSwNP) with stable CRS symptoms were enrolled to evaluate the reliability

SUBMITTER: Ghadersohi S 

PROVIDER: S-EPMC7448958 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature