Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with treatment resistance, unfavorable prognosis, and the infiltration of pro-tumorigenic macrophages.

Results

We explore the transcriptional regulatory networks of mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive the malignant phenotypic state of GBM, and identify macrophage receptor with collagenous structure (MARCO) as the most highly differentially expressed gene. MARCO^high TAMs induce a phenotypic shift towards mesenchymal cellular state of glioma stem cells, promoting both invas

SUBMITTER: Sa JK 

PROVIDER: S-EPMC7448990 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature