Mesenchymal stromal cells protect against vascular damage and depression-like behavior in mice surviving cerebral malaria.

ABSTRACT:

Background

Malaria is one of the most critical global infectious diseases. Severe systemic inflammatory diseases, such as cerebral malaria, lead to the development of cognitive and behavioral alterations, such as learning disabilities and loss of memory capacity, as well as increased anxiety and depression. The consequences are profound and usually contribute to reduce the patient's quality of life. There are no therapies to treat the neurological sequelae of cerebral malaria. Mesenchymal stromal cells (MSCs) may be an alternative, since they have been used as therapy for neurodegenerative diseases and traumatic lesions of the central nervous system. So far, no study has investigated the effects of MSC therapy on the blood-brain barrier, leukocyte rolling and adherence in the brain

SUBMITTER: Lima MN 

PROVIDER: S-EPMC7448996 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature