CXCR4⁺ cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis.

ABSTRACT:

Background

CXCR4, a transmembrane-receptor located on epithelial cells that is activated by CXCL12, may have a role in IPF via migration of CXCR4⁺ fibrocytes to the lung. However, its expression has not been fully characterised in idiopathic pulmonary fibrosis (IPF) or other fibrotic interstitial lung diseases (ILDs). CXCL12 is constitutively expressed in the bone marrow, and levels of CXCR4 regulate control of this signalling pathway. The aim of this study was to profile the expression of CXCR4 in lung tissue and peripheral circulation of patients with IPF and other fibrotic ILDs.

Methods

Expression of CXCR4 on peripheral blood mononuclear cells (PBMCs) was examined by flow cytometry in 20 patients with IPF and 10 age-matched non-disease control (NDC) donors. Lev

SUBMITTER: Jaffar J 

PROVIDER: S-EPMC7449054 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature