Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes.

ABSTRACT:

Background

The intra-erythrocytic development of the malaria parasite Plasmodium falciparum depends on the uptake of a number of essential nutrients from the host cell and blood plasma. It is widely recognized that the parasite imports low molecular weight solutes from the plasma and the consumption of these nutrients by P. falciparum has been extensively analysed. However, although it was already shown that the parasite also imports functional proteins from the vertebrate host, the internalization route through the different infected erythrocyte membranes has not yet been elucidated. In order to further understand the uptake mechanism, the study examined the trafficking of human plasminogen from the extracellular medium into P. falciparum-infected red blood cells.

Methods

P

SUBMITTER: El Chamy Maluf S 

PROVIDER: S-EPMC7449074 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature