Hormonal determinants of mammographic density and density change.

ABSTRACT:

Background

Mammographic density (MD) is a strong risk factor for breast cancer. We examined how endogenous plasma hormones are associated with average MD area (cm²) and annual MD change (cm²/year).

Methods

This study within the prospective KARMA cohort included analyses of plasma hormones of 1040 women. Hormones from the progestogen (n = 3), androgen (n = 7), oestrogen (n = 2) and corticoid (n = 5) pathways were analysed by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS), as well as peptide hormones and proteins (n = 2). MD was measured as a dense area using the STRATUS method (mean over the left and right breasts) and mean annual MD change over time.

Results

Greater baseline mean MD was associated with

SUBMITTER: Gabrielson M 

PROVIDER: S-EPMC7449090 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature