Projections of incident atherosclerotic cardiovascular disease and incident type 2 diabetes across evolving statin treatment guidelines and recommendations: A modelling study.

ABSTRACT:

Background

Experimental and observational research has suggested the potential for increased type 2 diabetes (T2D) risk among populations taking statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, few studies have directly compared statin-associated benefits and harms or examined heterogeneity by population subgroups or assumed treatment effect. Thus, we compared ASCVD risk reduction and T2D incidence increases across 3 statin treatment guidelines or recommendations among adults without a history of ASCVD or T2D who were eligible for statin treatment initiation.

Methods and findings

Simulations were conducted using Markov models that integrated data from contemporary population-based studies of non-Hispanic African American and whit

SUBMITTER: Engeda JC 

PROVIDER: S-EPMC7449387 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature