Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation.

ABSTRACT: We examined whether specifically statins, of the major lipid modifiers (statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects on ischemic heart disease (IHD) via testosterone in men or women. As a validation, we similarly assessed whether a drug that unexpectedly likely increases IHD also operates via testosterone. Using previously published genetic instruments we conducted a sex-specific univariable and multivariable Mendelian randomization study in the UK Biobank, including 179918 men with 25410 IHD cases and 212080 women with 12511 IHD cases. Of these three lipid modifiers, only genetically mimicking the effects of statins in men affected testosterone, which partly mediated effects on IHD. Correspondingly, genetically mimicking

SUBMITTER: Schooling CM 

PROVIDER: S-EPMC7449694 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature