Neurons that regulate mouse torpor.

ABSTRACT: The advent of endothermy, which is achieved through the continuous homeostatic regulation of body temperature and metabolism^1,2, is a defining feature of mammalian and avian evolution. However, when challenged by food deprivation or harsh environmental conditions, many mammalian species initiate adaptive energy-conserving survival strategies-including torpor and hibernation-during which their body temperature decreases far below its homeostatic set-point^3-5. How homeothermic mammals initiate and regulate these hypothermic states remains largely unknown. Here we show that entry into mouse torpor, a fasting-induced state with a greatly decreased metabolic rate and a body temperature as low as 20 °C⁶, is regulated by neurons in the medial and lateral preoptic

SUBMITTER: Hrvatin S 

PROVIDER: S-EPMC7449701 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature