Incidence of venous thromboembolism following initiation of non-steroidal anti-inflammatory drugs in U.S. women.

ABSTRACT:

Objective

To evaluate the risk of venous thromboembolism (VTE, i.e. deep vein thrombosis or pulmonary embolism, or both) following new use of NSAIDs in a long-term cohort of U.S. women.

Methods

We investigated initiation of coxibs and traditional NSAIDs (excluding aspirin) and incident VTE in 39 876 women enrolled in the Women's Health Study from 1993-95 and followed with yearly questionnaires until 2012. We defined initiation as the first reported use of NSAIDs for ≥4 days per month. Incident VTE was confirmed by an end point committee. We estimated hazard ratios (HRs) and risk differences (RDs, expressed as percentages) comparing NSAID initiation with non-initiation and acetaminophen initiation (active comparator) via standardization using a propensity score that incorpora

SUBMITTER: Kinsey TL 

PROVIDER: S-EPMC7449805 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature