Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis.

ABSTRACT: There is an established, link between psychosis and metabolic abnormalities, such as altered glucose metabolism and dyslipidemia, which often precede the initiation of antipsychotic treatment. It is known that obesity-associated metabolic disorders are promoted by activation of specific cannabinoid targets (endocannabinoid system (ECS)). Our recent data suggest that there is a change in the circulating lipidome at the onset of first episode psychosis (FEP). With the aim of characterizing the involvement of the central and peripheral ECSs, and their mutual associations; here, we performed a combined neuroimaging and metabolomic study in patients with FEP and healthy controls (HC). Regional brain cannabinoid receptor type 1 (CB1R) availability was quantified in two, independent samples of pa

SUBMITTER: Dickens AM 

PROVIDER: S-EPMC7450081 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature