Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity.

ABSTRACT: Viperin plays an important and multifaceted role in the innate immune response to viral infection. Viperin is also notable as one of very few radical SAM-dependent enzymes present in higher animals; however, the enzyme appears broadly conserved across all kingdoms of life, which suggests that it represents an ancient defense mechanism against viral infections. Although viperin was discovered some 20 years ago, only recently was the enzyme's structure determined and its catalytic activity elucidated. The enzyme converts CTP to 3'-deoxy-3',4'-didehydro-CTP, which functions as novel chain-terminating antiviral nucleotide when misincorporated by viral RNA-dependent RNA polymerases. Moreover, in higher animals, viperin interacts with numerous other host and viral proteins, and it is apparent th

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC7450102 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature