Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches.

ABSTRACT:

Background

Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family. This study aimed to design a potential multi-epitopes vaccine against infectious bronchitis virus spike protein (S). Protein characterization was also performed for IBV spike protein.

Methods

The present study used various tools in Immune Epitope Database (IEDB) to predict conserved B and T cell epitopes against IBV spike (S) protein that may perform a significant role in provoking the resistance response to IBV infection.

Results

In B cell prediction methods, three epitopes ( ₁₁₃₉ KKSSYY ₁₁₄₄

SUBMITTER: Awadelkareem EA 

PROVIDER: S-EPMC7450164 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature