Carotid Plaque Morphology is Similar in Patients with Reduced and Normal Renal Function.

ABSTRACT:

Background

Chronic Kidney Disease (CKD) is associated with an increased risk for cardiovascular events such as stroke. However, it is still unclear if decreased kidney function is associated with a vulnerable atherosclerotic plaque phenotype. To explore if renal function was associated with carotid plaque vulnerability we analyzed carotid plaques obtained at surgery from the Carotid Plaque Imaging Project (CPIP).

Methods

Patients were enrolled through the CPIP cohort. The indication for surgery was plaques with stenosis >70%, associated with ipsilateral symptoms or plaques with stenosis >80% not associated with symptoms. Transversal sections from the most stenotic plaque region were analyzed for connective tissue, calcium, lipids, macrophages, intraplaque hemorrhage, and smo

SUBMITTER: Heijl C 

PROVIDER: S-EPMC7450288 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature