Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

ABSTRACT:

Importance

Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.

Objective

To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia.

Design, setting, and participants

Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expr

SUBMITTER: Writing Committee for the Attention-Deficit/Hyperactivity Disorder 

PROVIDER: S-EPMC7450410 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature