Dataset Information

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

ABSTRACT:

Importance

Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.

Objective

To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia.

Design, setting, and participants

Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244.

Main outcomes and measures

Interregional profiles of group difference in cortical thickness between cases and controls.

Results

A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders.

Conclusions and relevance

In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.

SUBMITTER: Writing Committee for the Attention-Deficit/Hyperactivity Disorder

PROVIDER: S-EPMC7450410 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

Patel Yash Y Parker Nadine N Shin Jean J Howard Derek D French Leon L Thomopoulos Sophia I SI Pozzi Elena E Abe Yoshinari Y Abé Christoph C Anticevic Alan A Alda Martin M Aleman Andre A Alloza Clara C Alonso-Lana Silvia S Ameis Stephanie H SH Anagnostou Evdokia E McIntosh Andrew A AA Arango Celso C Arnold Paul D PD Asherson Philip P Assogna Francesca F Auzias Guillaume G Ayesa-Arriola Rosa R Bakker Geor G Banaj Nerisa N Banaschewski Tobias T Bandeira Cibele E CE Baranov Alexandr A Bargalló Núria N Bau Claiton H D CHD Baumeister Sarah S Baune Bernhard T BT Bellgrove Mark A MA Benedetti Francesco F Bertolino Alessandro A Boedhoe Premika S W PSW Boks Marco M Bollettini Irene I Del Mar Bonnin Caterina C Borgers Tiana T Borgwardt Stefan S Brandeis Daniel D Brennan Brian P BP Bruggemann Jason M JM Bülow Robin R Busatto Geraldo F GF Calderoni Sara S Calhoun Vince D VD Calvo Rosa R Canales-Rodríguez Erick J EJ Cannon Dara M DM Carr Vaughan J VJ Cascella Nicola N Cercignani Mara M Chaim-Avancini Tiffany M TM Christakou Anastasia A Coghill David D Conzelmann Annette A Crespo-Facorro Benedicto B Cubillo Ana I AI Cullen Kathryn R KR Cupertino Renata B RB Daly Eileen E Dannlowski Udo U Davey Christopher G CG Denys Damiaan D Deruelle Christine C Di Giorgio Annabella A Dickie Erin W EW Dima Danai D Dohm Katharina K Ehrlich Stefan S Ely Benjamin A BA Erwin-Grabner Tracy T Ethofer Thomas T Fair Damien A DA Fallgatter Andreas J AJ Faraone Stephen V SV Fatjó-Vilas Mar M Fedor Jennifer M JM Fitzgerald Kate D KD Ford Judith M JM Frodl Thomas T Fu Cynthia H Y CHY Fullerton Janice M JM Gabel Matt C MC Glahn David C DC Roberts Gloria G Gogberashvili Tinatin T Goikolea Jose M JM Gotlib Ian H IH Goya-Maldonado Roberto R Grabe Hans J HJ Green Melissa J MJ Grevet Eugenio H EH Groenewold Nynke A NA Grotegerd Dominik D Gruber Oliver O Gruner Patricia P Guerrero-Pedraza Amalia A Gur Raquel E RE Gur Ruben C RC Haar Shlomi S Haarman Bartholomeus C M BCM Haavik Jan J Hahn Tim T Hajek Tomas T Harrison Benjamin J BJ Harrison Neil A NA Hartman Catharina A CA Whalley Heather C HC Heslenfeld Dirk J DJ Hibar Derrek P DP Hilland Eva E Hirano Yoshiyuki Y Ho Tiffany C TC Hoekstra Pieter J PJ Hoekstra Liesbeth L Hohmann Sarah S Hong L E LE Höschl Cyril C Høvik Marie F MF Howells Fleur M FM Nenadic Igor I Jalbrzikowski Maria M James Anthony C AC Janssen Joost J Jaspers-Fayer Fern F Xu Jian J Jonassen Rune R Karkashadze Georgii G King Joseph A JA Kircher Tilo T Kirschner Matthias M Koch Kathrin K Kochunov Peter P Kohls Gregor G Konrad Kerstin K Krämer Bernd B Krug Axel A Kuntsi Jonna J Kwon Jun Soo JS Landén Mikael M Landrø Nils I NI Lazaro Luisa L Lebedeva Irina S IS Leehr Elisabeth J EJ Lera-Miguel Sara S Lesch Klaus-Peter KP Lochner Christine C Louza Mario R MR Luna Beatriz B Lundervold Astri J AJ MacMaster Frank P FP Maglanoc Luigi A LA Malpas Charles B CB Portella Maria J MJ Marsh Rachel R Martyn Fiona M FM Mataix-Cols David D Mathalon Daniel H DH McCarthy Hazel H McDonald Colm C McPhilemy Genevieve G Meinert Susanne S Menchón José M JM Minuzzi Luciano L Mitchell Philip B PB Moreno Carmen C Morgado Pedro P Muratori Filippo F Murphy Clodagh M CM Murphy Declan D Mwangi Benson B Nabulsi Leila L Nakagawa Akiko A Nakamae Takashi T Namazova Leyla L Narayanaswamy Janardhanan J Jahanshad Neda N Nguyen Danai D DD Nicolau Rosa R O'Gorman Tuura Ruth L RL O'Hearn Kirsten K Oosterlaan Jaap J Opel Nils N Ophoff Roel A RA Oranje Bob B García de la Foz Victor Ortiz VO Overs Bronwyn J BJ Paloyelis Yannis Y Pantelis Christos C Parellada Mara M Pauli Paul P Picó-Pérez Maria M Picon Felipe A FA Piras Fabrizio F Piras Federica F Plessen Kerstin J KJ Pomarol-Clotet Edith E Preda Adrian A Puig Olga O Quidé Yann Y Radua Joaquim J Ramos-Quiroga J Antoni JA Rasser Paul E PE Rauer Lisa L Reddy Janardhan J Redlich Ronny R Reif Andreas A Reneman Liesbeth L Repple Jonathan J Retico Alessandra A Richarte Vanesa V Richter Anja A Rosa Pedro G P PGP Rubia Katya K KK Hashimoto Ryota R Sacchet Matthew D MD Salvador Raymond R Santonja Javier J Sarink Kelvin K Sarró Salvador S Satterthwaite Theodore D TD Sawa Akira A Schall Ulrich U Schofield Peter R PR Schrantee Anouk A Seitz Jochen J Serpa Mauricio H MH Setién-Suero Esther E Shaw Philip P Shook Devon D Silk Tim J TJ Sim Kang K Simon Schmitt S Simpson Helen Blair HB Singh Aditya A Skoch Antonin A Skokauskas Norbert N Soares Jair C JC Soreni Noam N Soriano-Mas Carles C Spalletta Gianfranco G Spaniel Filip F Lawrie Stephen M SM Stern Emily R ER Stewart S Evelyn SE Takayanagi Yoichiro Y Temmingh Henk S HS Tolin David F DF Tomecek David D Tordesillas-Gutiérrez Diana D Tosetti Michela M Uhlmann Anne A van Amelsvoort Therese T van der Wee Nic J A NJA van der Werff Steven J A SJA van Haren Neeltje E M NEM van Wingen Guido A GA Vance Alasdair A Vázquez-Bourgon Javier J Vecchio Daniela D Venkatasubramanian Ganesan G Vieta Eduard E Vilarroya Oscar O Vives-Gilabert Yolanda Y Voineskos Aristotle N AN Völzke Henry H von Polier Georg G GG Walton Esther E Weickert Thomas W TW Weickert Cynthia Shannon CS Weideman Andrea S AS Wittfeld Katharina K Wolf Daniel H DH Wu Mon-Ju MJ Yang T T TT Yang Kun K Yoncheva Yuliya Y Yun Je-Yeon JY Cheng Yuqi Y Zanetti Marcus V MV Ziegler Georg C GC Franke Barbara B Hoogman Martine M Buitelaar Jan K JK van Rooij Daan D Andreassen Ole A OA Ching Christopher R K CRK Veltman Dick J DJ Schmaal Lianne L Stein Dan J DJ van den Heuvel Odile A OA Turner Jessica A JA van Erp Theo G M TGM Pausova Zdenka Z Thompson Paul M PM Paus Tomáš T

JAMA psychiatry 20210101 1

<h4>Importance</h4>Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.<h4>Objective</h4>To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obse ...[more]

PMID: 32857118

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Dataset Information

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

Importance

Objective

Design, setting, and participants

Main outcomes and measures

Results

Conclusions and relevance

Publications

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

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