Constructing cancer patient-specific and group-specific gene networks with multi-omics data.

ABSTRACT:

Background

Cancer is a complex and heterogeneous disease with many possible genetic and environmental causes. The same treatment for patients of the same cancer type often results in different outcomes in terms of efficacy and side effects of the treatment. Thus, the molecular characterization of individual cancer patients is increasingly important to find an effective treatment. Recently a few methods have been developed to construct cancer sample-specific gene networks based on the difference in the mRNA expression levels between the cancer sample and reference samples.

Methods

We constructed a patient-specific network with multi-omics data based on the difference between a reference network and a perturbed reference network by the patient. A network specific to a group of

SUBMITTER: Lee W 

PROVIDER: S-EPMC7450550 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature