Effects of long-term sleep disruption on cognitive function and brain amyloid-β burden: a case-control study.

ABSTRACT:

Background

Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer's disease by influencing the production and/or clearance of the amyloid-β protein. We set up a case-control study to investigate the association between long-term work-induced sleep disruption, cognitive function, and brain amyloid-β burden.

Methods

Nineteen male maritime pilots (aged 48-60 years) with chronic work-related sleep disruption and a sex-, age-, and education-matched control sample (n = 16, aged 50-60 years) with normal sleep completed the study. Primary sleep disorders were ruled out with in-lab polysomnography. Additional sleep measurements were obtained at home using actigraphy, sleep-wake logs, and a single-lead EEG device. Cognitive function was assesse

SUBMITTER: Thomas J 

PROVIDER: S-EPMC7450576 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature