Yb(OTf)₃-Catalyzed and Di-tert-butyl Dicarbonate-Mediated Decarboxylative Etherification and Esterification Reactions.

ABSTRACT: Protecting group chemistry has invariably captured the fascination of chemists because of its extensive viability in chemical synthesis. The present report describes our pioneer work of applying ytterbium triflate as a catalyst, for the reaction of alcohols with di-tert-butyl dicarbonate (Boc₂O) leading to the formation of tert-butyl ethers. There exists no recorded evidence for the use of Yb(OTf)₃ as a catalyst for the protection of alcohols to tert-butyl ethers, despite its excellent utility in various reactions. Yb(OTf)₃ has been used predominantly in the catalytic deprotection studies such as selective deprotection of tert-butyl esters to carboxylic acids as well as prenyl ethers to alcohols. This study involved the critical

SUBMITTER: Kaur A 

PROVIDER: S-EPMC7450632 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature