Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection.
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ABSTRACT:
SUBMITTER: Beier UH
PROVIDER: S-EPMC7450764 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection.
Beier Ulf H UH Hartung Erum A EA Concors Seth S Hernandez Paul T PT Wang Zhonglin Z Perry Caroline C Baur Joseph A JA Denburg Michelle R MR Hancock Wayne W WW Gade Terence P TP Levine Matthew H MH
Metabolomics : Official journal of the Metabolomic Society 20200504 5
To examine metabolic differences between renal allograft acute cellular rejection (ACR) and ischemic-reperfusion injury (IRI), we transplanted MHC-mismatched kidneys and induced 28 min warm-IRI, and collected the ACR and IRI kidneys as well as their respective native and collateral control kidneys. We extracted metabolites from the kidney tissues and found the lysine catabolite saccharopine 12.5-fold enriched in IRI kidneys, as well as the immunometabolites itaconate and kynurenine in ACR kidney ...[more]
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