Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.

ABSTRACT: Biomimetic materials with biomechanical properties resembling those of native tissues while providing an environment for cell growth and tissue formation, are vital for tissue engineering (TE). Mechanical anisotropy is an important property of native cardiovascular tissues and directly influences tissue function. This study reports fabrication of anisotropic cell-seeded constructs while retaining control over the construct's architecture and distribution of cells. Newly synthesized poly-4-hydroxybutyrate (P4HB) is fabricated with a dry spinning technique to create anelastomeric fibrous scaffold that allows control of fiber diameter, porosity, and rate ofdegradation. To allow cell and tissue ingrowth, hybrid scaffolds with mesenchymalstem cells (MSCs) encapsulated in a photocrosslinkable hy

SUBMITTER: Masoumi N 

PROVIDER: S-EPMC7450820 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature