Direct Amination of α-Hydroxy Amides.

ABSTRACT: A TiCl₄-mediated reaction for the direct amination of α-hydroxy amides has been developed. This simple, general, additive/base/ligand-free reaction is mediated by economical TiCl₄. The reaction runs under mild conditions. This highly efficient C-N bond formation protocol is valid for diverse amines, including primary, secondary and heterocyclic amines, and even a primary amide and indole.

SUBMITTER: Chandgude AL 

PROVIDER: S-EPMC7451067 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature