Effective connectivity of the right anterior insula in schizophrenia: The salience network and task-negative to task-positive transition.

ABSTRACT: Triple network dysfunction theory of schizophrenia postulates that the interaction between the default-mode and the fronto-parietal executive network is disrupted by aberrant salience signals from the right anterior insula (rAI). To date, it is not clear how the proposed resting-state disruption translates to task-processing inefficiency in subjects with schizophrenia. Using a contiguous resting and 2-back task performance fMRI paradigm, we quantified the change in effective connectivity that accompanies rest-to-task state transition in 29 clinically stable patients with schizophrenia and 31 matched healthy controls. We found an aberrant task-evoked increase in the influence of the rAI to both executive (Cohen's d = 1.35, p = 2.8 × 10^-6) and default-mode (Cohen's d = 1.22, p = 1

SUBMITTER: Luo Q 

PROVIDER: S-EPMC7451428 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature