Magnetic resonance imaging in multiple sclerosis animal models: A systematic review, meta-analysis, and white paper.

ABSTRACT: Magnetic resonance imaging (MRI) is the most important paraclinical tool for assessing drug response in multiple sclerosis (MS) clinical trials. As such, MRI has also been widely used in preclinical research to investigate drug efficacy and pathogenic aspects in MS animal models. Keeping track of all published preclinical imaging studies, and possible new therapeutic approaches, has become difficult considering the abundance of studies. Moreover, comparisons between studies are hampered by methodological differences, especially since small differences in an MRI protocol can lead to large differences in tissue contrast. We therefore provide a comprehensive qualitative overview of preclinical MRI studies in the field of neuroinflammatory and demyelinating diseases, aiming to summarize experi

SUBMITTER: Ineichen BV 

PROVIDER: S-EPMC7451445 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature