A molecular device: A DNA molecular lock driven by the nicking enzymes.

ABSTRACT: As people are placing more and more importance on information security, how to realize the protection of information has become a hotspot of current research. As a security device, DNA molecular locks have great potential to realize information protection at the molecular level. However, building a highly secure molecular lock is still a serious challenge. Therefore, taking advantage of the DNA strand displacement and enzyme control technology, we constructed a molecular lock with a self-destructive mechanism. This molecular lock is mainly composed of logic circuits and takes nicking enzymes as inputs. To build this molecular lock, we first constructed a series of cascade circuits, including a YES-YES cascade circuit and a YES-AND cascade circuit. Then, an Inhibit logic gate was constructe

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7451616 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature