Individual response to antidepressants for depression in adults-a meta-analysis and simulation study.

ABSTRACT:

Background

The observation that some patients appear to respond better to antidepressants for depression than others encourages the assumption that the effect of antidepressants differs between individuals and that treatment can be personalized.

Objective

To compare the outcome variance in patients receiving antidepressants with the outcome variance in patients receiving placebo in randomized controlled trials (RCTs) of adults with major depressive disorder (MDD) and to illustrate, using simulated data, components of variation of RCTs.

Methods

From a dataset comprising 522 RCTs of antidepressants for adult MDD, we selected the placebo-controlled RCTs reporting outcomes on the 17 or 21 item Hamilton Depression Rating Scale or the Montgomery-Asberg Depression Rating Sca

SUBMITTER: Munkholm K 

PROVIDER: S-EPMC7451660 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature