Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance.

ABSTRACT: The literature is replete with clinical studies that characterize the structure, diversity, and function of the gut microbiome and correlate the results to different disease states, including obesity. Whether the microbiome has a direct impact on obesity has not been established. To address this gap, we asked whether the gut microbiome and its bioenergetics quantitatively change host energy balance. This paper describes the design of a randomized crossover clinical trial that combines outpatient feeding with precisely controlled metabolic phenotyping in an inpatient metabolic ward. The target population was healthy, weight-stable individuals, age 18-45 and with a body mass index ≤30 kg/m². Our primary objective was to determine within-participant differences in energy balance af

SUBMITTER: Corbin KD 

PROVIDER: S-EPMC7451766 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature