Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat's kidney and HEK-293 cells.

ABSTRACT: Quercetin and gallic acid are phytochemicals with interesting pharmacological properties. We herein investigated the protective effect of quercetin (QUE) in comparison with gallic acid (GAL) against exogenously-induced oxidative damage in rats' kidney and human embryonic kidney (HEK-293) cell lines. Adult Wistar rats were treated with QUE and GAL (50 mg/kg) separately or in combination with di-n-butylphthalate (DnBP) for 14 days; and HEK-293 cells were treated with different concentrations of GAL (25-294 μM) or QUE (2-17 μM or 28-165.43 μM) singly or in combination with H₂O₂ (200 μM). After treatment, the kidney and cell extracts were processed for biochemical analysis and histopathology. We found that GAL but not QUE prevented DnBP-induced increase in lipid peroxidat

SUBMITTER: Abarikwu SO 

PROVIDER: S-EPMC7451806 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature