Primate differential redoxome (PDR) - A paradigm for understanding neurodegenerative diseases.

ABSTRACT: Despite different phenotypic manifestations, mounting evidence points to similarities in the molecular basis of major neurodegenerative diseases (ND). CNS has evolved to be robust against hazard of ROS, a common perturbation aerobic organisms are confronted with. The trade-off of robustness is system's fragility against rare and unexpected perturbations. Identifying the points of CNS fragility is key for understanding etiology of ND. We postulated that the 'primate differential redoxome' (PDR), an assembly of proteins that contain cysteine residues present only in the primate orthologues of mammals, is likely to associate with an added level of regulatory functionalities that enhanced CNS robustness against ROS and facilitated evolution. The PDR contains multiple deterministic and suscepti

SUBMITTER: Venkatachalam N 

PROVIDER: S-EPMC7451816 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature