Flexible electrical stimulation device with Chitosan-Vaseline® dressing accelerates wound healing in diabetes.

ABSTRACT: The healing process of diabetic wounds is typically disordered and prolonged and requires both angiogenesis and epithelialization. Disruptions of the endogenous electric fields (EFs) may lead to disordered cell migration. Electrical stimulation (ES) that mimics endogenous EFs is a promising method in treating diabetic wounds; however, a microenvironment that facilitates cell migration and a convenient means that can be used to apply ES are also required. Chitosan-Vaseline® gauze (CVG) has been identified to facilitate wound healing; it also promotes moisture retention and immune regulation and has antibacterial activity. For this study, we created a wound dressing using CVG together with a flexible ES device and further evaluated its potential as a treatment for diabetic wounds. We found t

SUBMITTER: Wang XF 

PROVIDER: S-EPMC7451868 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature