Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.

ABSTRACT: Pleiotropy-when a single mutation affects multiple traits-is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such that every gene has the potential to affect many traits. Pleiotropy is also critical to initiatives in evolutionary medicine that seek to trap infectious microbes or tumors by selecting for mutations that encourage growth in some conditions at the expense of others. Research in these fields, and others, would benefit from understanding the extent to which pleiotropy reflects inherent relationships among phenotypes that correlate no matter the perturbation (vertical pleiotropy). Alternatively, pleiotropy may result from genetic changes that

SUBMITTER: Geiler-Samerotte KA 

PROVIDER: S-EPMC7451985 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature