The effects of intranasal oxytocin in opioid-dependent individuals and healthy control subjects: a pilot study.

ABSTRACT:

Rationale

There has been an explosion of research on the potential benefits of the social neuropeptide oxytocin for a number of mental disorders including substance use disorders. Recent evidence suggests that intranasal oxytocin has both direct anti-addiction effects and pro-social effects that may facilitate engagement in psychosocial treatment for substance use disorders.

Objectives

We aimed to assess the tolerability of intranasal oxytocin and its effects on heroin craving, implicit association with heroin and social perceptual ability in opioid-dependent patients receiving opioid replacement therapy (ORT) and healthy control participants.

Methods

We performed a randomized, double-blind, placebo-controlled, within- and between-subjects, crossover, proof-of-concept

SUBMITTER: Woolley JD 

PROVIDER: S-EPMC7452038 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature