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Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in Mice.

ABSTRACT: Dengue virus (DENV) infection is a major global public health concern, and there is no effective vaccine for it. In this study, we describe the design and characterization of three nucleotide-modified mRNA vaccines (prME-mRNA, E80-mRNA, and NS1-mRNA) for DENV-2. Our results showed that vaccination with E80-mRNA alone or a combination of E80-mRNA and NS1-mRNA can induce high levels of neutralizing antibodies and antigen-specific T cell responses; furthermore, these vaccines confer complete protection against DENV-2 challenge in immunocompetent mice. These data provide foundations for further development of a tetravalent DENV vaccine based on nucleotide-modified mRNA.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7452130 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in Mice.

Zhang Mengling M   Sun Jin J   Li Min M   Jin Xia X  

Molecular therapy. Methods & clinical development 20200721

Dengue virus (DENV) infection is a major global public health concern, and there is no effective vaccine for it. In this study, we describe the design and characterization of three nucleotide-modified mRNA vaccines (prME-mRNA, E80-mRNA, and NS1-mRNA) for DENV-2. Our results showed that vaccination with E80-mRNA alone or a combination of E80-mRNA and NS1-mRNA can induce high levels of neutralizing antibodies and antigen-specific T cell responses; furthermore, these vaccines confer complete protec  ...[more]

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